China Science

OBJECTIVE: To assess the validity of SurePath liquid-based preparation methodfor examination of endocervical brush specimens as a substitute for conventionally preparedcytology methods for evaluating the endocervical canal during colposcopic examination and biopsy.STUDY DESIGN: Paired SurePath liquid-based test slides and conventional smears were obtained usingan endocervical brush in a split sample protocol before biopsy at the time of colposcopy. The levelof agreement between cytologic results obtained was assessed. Accuracy and operating characteristicswere evaluated compared to histologic follow-up. RESULTS: Agreement between cytology results forthe methods was excellent. The overall kappa was 0.924 (p = 0.0000). There was exact agreement oninterpretation between the methods in 283 of 299 cases (94.6%). Cytohistologic follow-up resultscorrelation were: SurePath liquid-based Pap test results and conventional smear results agreed withhistology results in 47.8% and 49.2% of cases, respectively. Allowing for a discrepancy within 1level of severity of cytologic grade, agreements were 76.6% and 77.2%, respectively. CONCLUSION:This study demonstrates that the SurePath method is equivalent to conventional endocervical brushcytology preparation and performs well for detection of cervical intraepithelial lesions and cancer.SurePath is acceptable for endocervical evaluation as a substitute for endocervical curettage atcolposcopic biopsy.

Kim,HS　Park,JS　Park,JY　Hong,SR　Seong,SJ　Kim,HS　Wilbur,DC
Department of Pathology, Cheil General Hospital and Women’s HealthcareCenter, Kwandong University College of Medicine, Seoul, Republic of Korea.

Adolescent　 Adult　 Aged　 Carcinoma, Squamous Cell　 Cervix Uteri CytologicalTechniques