China Science

OBJECTIVE: To evaluate the value of cytologic examination in the diagnosis oflaryngeal tumors. STUDY DESIGN: A series of 100 patients with suspected tumorous lesions of thelarynx were included in the study. The material for cytologic analysis was obtained by use of amodified instrument, that is, a slightly concave discoid knife, during direct microlaryngoscopy,followed by biopsy for paraffin and frozen section histopathology. The findings obtained by cytologyand frozen section histopathology were compared with the findings of paraffin sectionhistopathology. RESULTS: Cytology showed an 83.9% sensitivity, 100% specificity and 90% accuracycompared with histopathologic findings (p < 0.05; chi2 = 7.7). Frozen section pathohistology vs.paraffin section histopathology showed an 80.6% sensitivity, 97.4% specificity and 87% accuracy (p <0.05; chi2 = 8.1). CONCLUSION: Cytologic examination showed higher accuracy compared to frozensection histopathology, also giving an insight into the type of laryngealpathology in the case ofprecancerous lesions. The use of cytology and frozen section histopathology during directmicrolaryngoscopy improves clinical diagnostic accuracy.

Cikojevic,D　Gluncic,I　Pesutic-Pisac,V
Ear, Nose and Throat Department, Split University Hospital, Split, Croatia.drasko.cikojevic@st.t-com.hr

Carcinoma, Squamous Cell　 Cytodiagnosis　 Female　 Frozen Sections Humans