Cell cannibalism and nucleus-fragmented cells in voided urine: usefulparameters for cytologic diagnosis of low-grade urothelial carcinoma.
OBJECTIVE: To clarify whether the 3 parameters of cell clusters, cellcannibalism and nucleus-fragmented cells could improve diagnostic accuracy for grade 1 urothelialcarcinoma (G1UC). STUDY DESIGN: A total of 52 voided urine samples from 31 patients histologicallydiagnosed as having G1UC were reviewed. In addition, 10 voided urine samples from cases with grade 3demonstration urothelial carcinoma (G3UC) and 30 voided urine samples from 25 patients with ahistologic diagnosis of chronic inflammation of the bladder were evaluated for comparison. Areas oftumor cells with cannibalism were measured. RESULTS: Cell cannibalism was evident in 12 of 31 G1UCcases (38.7%), significantly less often than with G3UC, but never identified in the control group.Mean areas of tumor cells featuring cannibalism were significantly smaller in G1 UC than in G3UCcases. Nucleus-fragmented cells were also less frequent in G1UC than in G3UC, but more common thanin the control group. CONCLUSION: Cell cannibalism and nucleus-fragmented cells in voided urine withspecial attention to areas of tumor cell with cannibalism could be applied as a parameter toimprove diagnostic accuracy for G1UC.
Hattori,M　Nishino,Y　Kakinuma,H　Matsumoto,K　Ohbu,M　Okayasu,I
Department of Clinical Cytology, School of Allied Health Sciences, KitasatoUniversity, Kanagawa, Japan. mhattori@nc.kitasato-u.ac.jp
Cells　 In Urine　 Carcinoma　 Diagnostic Neoplasms
