Orbital Rosai-Dorfman disease: report of a case with fine needle aspirationcytology and histopathology
BACKGROUND: Rosai-Dorfman disease, or sinus histiocytosis with massivelymphadenopathy (SHML), is a rare, nonhereditary, benign histiocytic proliferative disorder,affecting mainly the lymph nodes. Orbital involvement in the absence of lymphadenopathy isrelatively uncommon. CASE: A 50-year-old woman presented to our hospital with gradual proptosis ofthe left eye for 5 years. Physical examination revealed no abnormalities, including lymphadenopathy.Ultrasonography and magnetic resonance imaging showed a soft tissue mass in the intraconalretroorbital region of the left eye. Fine needle aspiration cytology of the mass yielded a goodnumber of mature lymphocytes, a few neutrophils, plasma cells and many histiocytes exhibitingemperipolesis. A provisional diagnosis of SHML was suggested and later confirmed by histology of theexcised mass. CONCLUSION: Though the orbit is a rare site of extranodal SHML, the disease should beentertained in the differential diagnosis of orbital swellings. To the best of our knowledge, thisis the fourth case of SHML involving the orbit exclusively, with no nodal involvement.
Malur,PR　Bannur,HB　Kodkany,SB
Department of Pathology, J. N. Medical College, Belgaum, Karnataka, India.dome@jnmc.edu
Orbital　 Enlargement of lymph nodes Fine needle biopsy, NOS Mass, NOS
