Role of surfactant; pH on dissolution properties of fenofibrate; glipizide—A technical note
Conclusions Depending on the dose size; solubility characteristics of low solubility drugs, a meaningful; discriminatory power of dissolution rate testing can be demonstrated. Saturation solubility of fenofibrate; glipizide in different media were determined. Solubility of fenofibrate increased directly with SLS concentration. For a 54-mg fenofibrate tablet, SLS at 0.025 M level is required for a discriminative dissolution test, while for 160-mg tablet, dissolution condition; levels of SLS should be optimized; higher concentrations may be effective (ie, 0.052 M, ?1.5%). A pH 6.8 phosphate buffer medium is appropriate for glipizide 10-mg tablet dissolution study, when formulation ingredients include excipients with surface activity (eg, HPMC).
Shahla Jamzad1?Reza Fassihi1Email:reza.fassihi@temple.edu
[1] School of Pharmacy, Temple University, 3307 N Broad Street, 19140 Philadelphia, PA
