Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention
The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 2[3] factorial design was employed in formulating the GFDDS with total polymer content-to-drug ratio (X1), polymer-to-polymer ratio (X2),; different viscosity grades of hydroxypropyl methyl cellulose (HPMC) (X3) as independent variables. Four dependent variables were considered: percentage of MT release at 8 hours, T50%, diffusion coefficient,; floating time. The main effect; interaction terms were quantitatively evaluated using a mathematical model. The results indicate that X1; X2 significantly affected the floating time; release properties, but the effect of different viscosity grades of HPMC (K4M; K10M) was nonsignificant. Regression analysis; numerical optimization were performed to identify the best formulation. Fickian release transport was confirmed as the release mechanism from the optimized formulation. The predicted values agreed well with the experimental values,; the results demonstrate the feasibility of the model in the development of GFDDS.
C. Narendra1Email:narendragcp@rediffmail.com?M. S. Srinath2?Ganesh Babu2
[1] Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore-34, India ;[2] Department of Pharmaceutics, Government College of Pharmacy, Bangalore-27, India ;[3] Department of Pharmaceutics, Visveswarapura Institute of Pharmaceutical Sciences, V.V. Puram, 560004 Bangalore, Karnataka, India
