Spherical agglomeration of mefenamic acid; nabumetone to improve micromeritics; solubility: A technical note
Conclusions Spherical agglomeration techniques were developed for improving the flow; compressibility characteristics of microcrystalline mefenamic acid; nabumetone. The process involved agglomerating microcrystals using agglomerating solvents. Temperature; speed of agitation were optimized to obtain spherical agglomerates in a desired range, which was found to be essential to enhance compressibility. Incorporation of polymer HPMC during agglomeration significantly enhanced the dissolution rate of mefenamic acid while incorporation of solubilizing agent lecithin improved the solubility of nabumetone. Thus, spherical agglomeration is an important technique for improving direct compressibility of pharmaceutical powders; is especially useful when the drug dosage is high.
Chelakara L. Viswanathan1Email:chelakara_viswanathan@yahoo.com?Sushrut K. Kulkarni1?Dhanashri R. Kolwankar1
[1] Bombay College of Pharmacy, Kalina, Santacruz ;[East], 400 098 Mumbai, India
