Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note
Conclusions The ionotropic gelation method for formation of crosslinked chitosan particles can be easily modified from ionic cross-linking to deprotonation by adjusting the pH of TPP. Chitosan was cross-linked ionically with TPP at lower pH; by deprotonation mechanism at higher pH. The swelling behavior of cross-linked chitosan appeared to depend on the pH of TPP. The ionically cross-linked chitosan showed higher swelling ability. Thus the nature of crosslinked chitosan can be tailor made to obtain the desired properties in terms of cross-linking density, crystallinity,; hydrophilicity.
Devika R. Bhumkar1?Varsha B. Pokharkar1Email:vbpokharkar@yahoo.co.in
[1] Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, 411038 Pune, Maharashtra State, India
