China Science

This study focused on an investigation of a high drug-loaded solid dispersion system consisting of drug, carrier,; surfactant. Solid dispersions of a water-insoluble ofloxacin (OFX) with polyethylene glycol (PEG) of different molecular weights, namely binary solid dispersion systems, were prepared at drug to carrier not less than 5?5. Polysorbate 80, a nonionic surfactant, was incorporated into the binary solid dispersion systems as the third component to obtain the ternary solid dispersion systems. The powder x-ray diffraction; differential scanning calorimetric studies indicated that crystalline OFX existed in the solid dispersions with high drug loading. However, a decreased crystallinity of the solid dispersions obtained revealed that a portion of OFX was in an amorphous state. The results indicated a remarkably improved dissolution of drug from the ternary solid dispersion systems when compared with the binary solid dispersion systems. This was because of polysorbate 80, which improved wettability; solubilized the non-molecularly dispersed or crystalline fraction of OFX.

Siriporn Okonogi1Email:sirioko@chiangmai.ac.th?Satit Puttipipatkhachorn2
[1] Faculty of Pharmacy, Dept. of Pharmaceutical Sciences, Chiang Mai University, 50200 Chiang Mai, Thailand ;[2] Faculty of Pharmacy, Dept. of Manufacturing Pharmacy, Mahidol University, 10400 Bangkok, Thailand