A mucoadhesive in situ gel delivery system for paclitaxel
MUC1 gene encodes a transmembrane mucin glycoprotein that is overexpressed in human breast cancer; colon cancer. The objective of this study was to develop an in situ gel delivery system containing paclitaxel (PTX); mucoadhesives for sustained; targeted delivery of anticancer drugs. The delivery system consisted of chitosan; glyceryl monooleate (GMO) in 0.33M citric acid containing PTX. The in vitro release of PTX from the gel was performed in presence; absence of Tween 80 at drug loads of 0.18%, 0.30%,; 0.54% (wt/wt), in Sorensen’s phosphate buffer (pH 7.4) at 37°C. Different mucin-producing cell lines (Calu-3
Saurabh Jauhari1?Alekha K. Dash1Email:adash@creighton.edu
[1] School of Pharmacy & Health Professions, Creighton University Medical Center, 2500 California Plaza, Omaha, NE
