Outcomes of women with atypical squamous cells of undetermined significanceand high-risk human papillomavirus DNA
OBJECTIVE: To study the risk of high-grade squamous intraepithelial lesion(HSIL) and cervical intraepithelial neoplasia (CIN) 2 or 3 in women with human papillomavirus(HPV)-positive atypical squamous cells of undetermined significance (ASCUS) cytology over a 2-yearperiod using the 2001 Bethesda System and ThinPrep Paps. STUDY DESIGN: In 2002, 846 patients withThinPrep cervical cytology having an ASCUS interpretation and positive for high-risk HPV DNA wereidentified. A cohort of 514 (60.8%) patients with follow-up by repeat cytology, cervical biopsy orboth was included in the study. Patient age was 12-81 years, with a median of 25 years. RESULTS:There were 291 women (56.6%) with negative status by cytology, HPV testing or biopsy with a medianinterval of 8.5 months, and an additional 174 patients (33.9%) had persistent ASCUS, positive HPVDNA or low-grade SIL/CIN 1. Finally, 49 patients (9.5%) had CIN 2 or 3, with a median interval of8.5 months. CONCLUSION: Our study suggests that HSIL or CIN 2 or 3 will be detected in 1 in 10 womenwith HPV-positive index ASCUS cervical cytology at initial colposcopy or within a 2-year follow-upperiod.
Feng,J　Husain,M
Department of Pathology and Cytopathology, Detroit Medical Center, WayneState University, Detroit, Michigan 48201, USA. jfeng@dmc.org
Adolescent　 Adult　 Age Distribution　 Aged　 Aged, 80 and overAlphapapillomavirus
