Contributions of the active and passive components of the cytoskeletalprestress to stiffening of airway smooth muscle cells.
Rosenblatt,N; Hu,S; Suki,B; Wang,N; Stamenovic,D
Abstract Airway smooth muscle cells exhibit stiffening during contractile activation.This stiffening may be interpreted as a result of the stabilizing influence of the mechanicalprestress stored within the cytoskeleton (CSK). However, in vivo, airway smooth muscle cellscontract while simultaneously experiencing breathing-induced stretching. Excessive stretching ofcells could cause actin-myosin crosslinks, and possibly other cytoskeletal filaments, (more…)










