Detection of molecular markers for chloroquine and pyrimethamine/sulfadoxineresistance in imported cases of Plasmodium falciparum malaria in Poland
The identified mutations in the pfcrt, dhfr and dhps genes of Plasmodiumfalciparum show a very high correlation with resistance to chloroquine, pyrimethamine andsulfadoxine, the drugs that are still used as malaria chemoprophylaxis or treatment. We undertook amolecular screening of 82 Polish P. falciparum isolates, mainly imported from different countries ofsub-Saharan Africa to assess their molecular drug-resistance profiles. (more…)
