Helical Tubuland Diols: A Synthetic and Crystal Engineering Quest

Despite many advances in recent years, crystal engineering remains a risky venture. A successful outcome requires manipulation of the noncovalent bonding and properties such as size, shape, repulsion, attraction, polarity, and chirality. In this Account, we describe the interplay of… Read moreHelical Tubuland Diols: A Synthetic and Crystal Engineering Quest

Complementary Structure Sensitive and Insensitive Catalytic Relationships

The burgeoning field of nanoscience has stimulated an intense interest in properties that depend on particle size. For transition metal particles, one important property that depends on size is catalytic reactivity, in which bonds are broken or formed on the… Read moreComplementary Structure Sensitive and Insensitive Catalytic Relationships

Sugars, Alkaloids, and Heteroaromatics: Exploring Heterocyclic Chemistry with Alkoxyallenes

As master craftsmen, modern synthetic chemists are challenged to achieve remarkable feats of efficiency and elegance toward molecular targets. The nature of this pursuit necessitates the collection of synthetic repertoires that are tried and true. With methodologies and pathways increasingly… Read moreSugars, Alkaloids, and Heteroaromatics: Exploring Heterocyclic Chemistry with Alkoxyallenes

Predicting Hydrogen-Bond Strengths from Acid?Base Molecular Properties. The pKa Slide Rule: Toward the Solution of a Long-Lasting Problem

Unlike normal chemical bonds, hydrogen bonds (H-bonds) characteristically feature binding energies and contact distances that do not simply depend on the donor (D) and acceptor (:A) nature. Instead, their chemical context can lead to large variations even for a same… Read morePredicting Hydrogen-Bond Strengths from Acid?Base Molecular Properties. The pKa Slide Rule: Toward the Solution of a Long-Lasting Problem

A Role for Water Molecules in DNA?Ligand Minor Groove Recognition

Targeting the minor groove of DNA through binding to a small molecule has long been considered an important molecular-recognition strategy in biology. A wide range of synthetic heterocyclic molecules bind noncovalently in the minor groove of the double helix and… Read moreA Role for Water Molecules in DNA?Ligand Minor Groove Recognition

Structural Color Films with Lotus Effects, Superhydrophilicity, and Tunable Stop-Bands

The structural blue color of a Morpho butterfly originates from the diffraction of light and interference effects due to the presence of the microstructures on the wing of the butterfly. Structural color on the surface of a damselfish reversibly changes… Read moreStructural Color Films with Lotus Effects, Superhydrophilicity, and Tunable Stop-Bands