Science Publications

Rosenblatt,N; Hu,S; Suki,B; Wang,N; Stamenovic,D

Abstract Airway smooth muscle cells exhibit stiffening during contractile activation.This stiffening may be interpreted as a result of the stabilizing influence of the mechanicalprestress stored within the cytoskeleton (CSK). However, in vivo, airway smooth muscle cellscontract while simultaneously experiencing breathing-induced stretching. Excessive stretching ofcells could cause actin-myosin crosslinks, and possibly other cytoskeletal filaments, (more…)

Hahn,MS; McHale,MK; Wang,E; Schmedlen,RH; West,JL

Abstract Mechanical conditioning represents a potential means to enhance thebiochemical and biomechanical properties of tissue engineered vascular grafts (TEVGs). (more…)

Hlastala,MP; Anderson,JC

Abstract Highly soluble gases exchange primarily with the bronchial circulationthrough pulmonary airway tissue. Because of this airway exchange, the assumption that end-exhaledalcohol concentration (EEAC) is equal to alveolar alcohol concentration (AAC) cannot be true. Duringexhalation, (more…)

McDonnell,P; McHugh,PE; O”Mahoney,D

Abstract Vertebral fractures due to osteoporosis commonly occur under non-traumaticloading conditions. This problem affects more than 1 in 3 women and 1 in 10 men over a lifetime.Measurement of bone mineral density (BMD) has traditionally been used as a method for diagnosis ofvertebral osteoporosis. However, this method does not fully account for the influence of changes inthe trabecular bone quality, such as micro-architecture, tissue properties and levels ofmicrodamage, on the strength of the vertebra. Studies have shown that deterioration of the vertebraltrabecular architecture results in a more anisotropic structure which has a greater susceptibilityto fracture. (more…)

Marsden,AL; Vignon-Clementel,IE; Chan,FP; Feinstein,JA; Taylor,CA

Abstract Congenital heart defects with a single functional ventricle, such ashypoplastic left heart syndrome and tricuspid atresia, require a staged surgical approach toseparate the systemic and pulmonary circulations. (more…)

Abstract The presence of cerebral evoked responses can be tested by using objectiveresponse detectors. They are statistical tests that provide a threshold above which responses can beassumed to have occurred. The detection power depends on the signal-to-noise ratio (SNR) of theresponse and the amount of data available. However, the correlation within the background noisecould also affect the power of such detectors. (more…)

Wallace,CS; Champion,JC; Truskey,GA

Abstract To evaluate interactions between human endothelial cells (ECs) and smoothmuscle cells (SMCs) for the development of tissue-engineered vessels, we examined the adhesion andkey cell properties of human ECs grown on quiescent human aortic SMCs. ECs attached to SMCs spreadmore slowly than ECs attached to fibronectin surfaces, and ECs aligned along the direction of theSMCs. (more…)

Abstract Convective delivery of nutrients is important to enhance mass transportwithin tissue engineered (TE) products. Depending on the target tissue, an ideal TE product willhave an integrated microvasculature that will eliminate mass transport limitations that can occurduring product growth in vitro and integration in vivo. A synthetic approach to developmicrovasculature involves development of network designs with efficient mass transfercharacteristics. (more…)