IntroductionThoracic trauma secondary to motor vehicle crashes (MVC) continues to be a major cause of morbidity and mortality. Specific vehicle features may increase the risk of severe thoracic injury when striking the occupant. (more…)
OBJECTIVE: Interpersonal psychotherapy (IPT) for depression is a brief, well researched treatment for acute major depression. This article describes the implementation of IPT as an evidence-based treatment for depression in a psychiatry residency program. (more…)
BACKGROUND: Carcinoma metastatic to the pituitary gland is infrequent and hasbeen reportedly detected in approximately 1% of pituitary surgical cases. It may masquerade as apituitary adenoma both clinically and radiologically. (more…)
OBJECTIVE: Recent studies have validated the use of cytologic materials todetermine HER-2/neu status. Good concordance has been shown between results obtained byimmunocytochemistry (more…)
OBJECTIVE: To investigate the impact of keratin on the accuracy of internal and external anal brush sampling of known lesions. STUDY DESIGN: A group of 46 human immunodeficiency virus (HIV)-seropositive patients underwent external and internal anal brush sampling before biopsy of known lesions. RESULTS; (more…)
OBJECTIVE: The recently developed software (CONQUISTADOR), capable of computing all intralaboratory and interlaboratory quality control (QC) indicators, was used to evaluate the diagnostic agreement among 4 cytology laboratories participating in the LAMS Study. STUDY DESIGN: (more…)
Deserranno,D; Kassemi,M; Thomas,JD
Abstract The success and usefulness of lumped cardiovascular models are directlydependent on the physiological fidelity of their formulation. In most existing lumped formulationsfor the heart, the compliance of the chamber is modeled based on its electrical analog, thecapacitor. This has traditionally resulted in the use of a pre-described time-varying stiffnessmodulus for simulating the cardiac contractions. Unfortunately, such a time-varying stiffness doesnot include any physiological contractile machinery and thus no dependency on fiber sarcomere lengthand intracellular calcium concentrations, key mechanisms responsible for proper cardiac function.In this paper a lumped cardiovascular model is presented that is based on the incorporation ofdetailed myofilament activation for simulating the ventricular calcium binding and cross-bridgingmechanism. Upon validation against experimental data, it is shown that the new myofilamentactivation-based model considerably increases the physiological validity andinternal consistency ofthe cardiovascular simulations in comparison to the traditional variable compliance-based models. Itis also shown, through specific case studies, that the present model can serve as a quick responsetool for testing various hypotheses concerning the impact of the calcium binding and crossbridgekinetics on the overall performance of the cardiovascular system.
Keywords Actins; Heart; Microfilaments; Models, Biological
Annals of Biomedical Engineering
0090-6964, Volume 35, Issue 3, 2007, Pages 3-336
Maner,WL; Garfield,RE
Abstract OBJECTIVE: To use artificial neural networks (ANNs) on uterineelectromyography (EMG) data to classify term/preterm labor/non-labor pregnant patients. MATERIALSAND METHODS: A total of 134 term and 51 preterm women (all ultimately delivered spontaneously) wereincluded. Uterine EMG was measured trans-abdominally using surface electrodes. (more…)
